Active Research Projects

Motor Neuron Development and Circuitry

We are studying how the neural circuitry that is required for coordinated walking in adult flies is constructed during development, and how it functions in the adult.

Recent Publication

An abx bx pbx/DfP2 four winged mutant. Photograph by Nicolas Gompel, University of Munich

Cell-type-specific Hox regulatory strategies orchestrate tissue identity

Ryan Loker
Jordyn Sanner
Richard S. Mann


August 08, 2021

A genomics perspective on the famous four-winged fly

In the 1950s and 1960s, Ed Lewis of Caltech discovered the homeodomain encoding genes we now refer to as the Hox genes. One of the most famous mutants that Lewis described is a mutant of the Hox gene Ultrabithorax (Ubx) where the third thoracic (T3) segment of the fly, which normally has a small pair of balancing appendages called halteres, is entirely transformed into a second copy of the second thoracic (T2) segment, with a complete pair of extra wings and second thoracic notum.

May 22, 2021

Welcome Nadeera

The Mann lab welcomes new postdoc Nadeera Wickramasinghe, who just started this past week. Nadeera did her PhD at Mt. Sinai, NYC, in the laboratory of Dr. Nicole Dubois. Nadeera "met" and decided to come to the lab with only virtual information, so it was especially fun to meet her in person this week!