Image Carousel with 11 slides
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Slide 1: Tarsal depressor MN dendrites
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Slide 2: Series of embryos with Hox-Exd binding sites successively mutated in a reporter gene
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Slide 7: Word jumble for the Mann lab
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Slide 8: Stochastic flybow labeling of individual neuropil glia
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Slide 9: Human towers of Catalonia by David Oliete
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Slide 10: A fly leg imaginal disc
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Slide 11: Four x-ray structures of AbdB-Exd bound to four different binding sites
Active Research Projects
The Control of Hox Specificity and Activity
We study how the Hox family of transcription factors bind to the correct DNA sequences and regulate the correct target genes in vivo.
Motor Neuron Development and Circuitry
We are studying how the neural circuitry that is required for coordinated walking in adult flies is constructed during development, and how it functions in the adult.
News
A deeper understanding of Hox specificity
A new level of understanding of Hox protein specificity in vivo is now described in this collaborative paper with Carlos Sánchez-Higueras and James C.-G. Hombria from the CSIC, Universidad Pablo de Olavide, Seville, Spain. In this paper, beautiful in vivo genetics is used to systematically vary Hox and Hox-cofactor binding sites in a cis-regulatory module from the ventral veinless (vvl) gene, which is normally under the control of multiple Hox proteins.
Low affinity binding site review
In this review article published in the Annual Review of Cell and Developmental Biology, we argue that low affinity binding sites, which provide critical specificity for members of transcription factor families, co-evolved with transcription factor hubs, which increase the local concentration of transcription factors, thus allowing low affinity sites to be occupied.
Dr. Venkatasubramanian
Congratulations to Lalanti who successfully defended her thesis, gave an awesome talk, and wowed her committee. Truly a Scientist of the World!
Photos
Dendrites and cell bodies of a pair of tarsal depressor motor neurons
Image from Manntastic event, June 14, 2019
Four x-ray structures of AbdB-Exd bound to four different binding sites