Active Research Projects

Motor Neuron Development and Circuitry

We are studying how the neural circuitry that is required for coordinated walking in adult flies is constructed during development, and how it functions in the adult.

Recent Publication

Transcription factor paralogs orchestrate alternative gene regulatory networks by context dependent cooperation with multiple cofactors

Siqian Feng
Chaitanya Rastogi
Ryan Loker
William Glassford
Tomas Rube
Harmen Bussemaker
Richard Mann


August 08, 2021

A genomics perspective on the famous four-winged fly

In the 1950s and 1960s, Ed Lewis of Caltech discovered the homeodomain encoding genes we now refer to as the Hox genes. One of the most famous mutants that Lewis described is a mutant of the Hox gene Ultrabithorax (Ubx) where the third thoracic (T3) segment of the fly, which normally has a small pair of balancing appendages called halteres, is entirely transformed into a second copy of the second thoracic (T2) segment, with a complete pair of extra wings and second thoracic notum.