Image Carousel with 12 slides
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Slide 1: Tarsal depressor MN dendrites
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Slide 2: Series of embryos with Hox-Exd binding sites successively mutated in a reporter gene
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Slide 7: Word jumble for the Mann lab
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Slide 8: Stochastic flybow labeling of individual neuropil glia
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Slide 9: Human towers of Catalonia by David Oliete
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Slide 10: A fly leg imaginal disc
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Slide 11: Four x-ray structures of AbdB-Exd bound to four different binding sites
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Slide 12: Single serotonergic neurons in the fly VNC
Active Research Projects
The Control of Hox Specificity and Activity
We study how the Hox family of transcription factors bind to the correct DNA sequences and regulate the correct target genes in vivo.
Motor Neuron Development and Circuitry
We are studying how the neural circuitry that is required for coordinated walking in adult flies is constructed during development, and how it functions in the adult.
Recent Publication
Dense and pleiotropic regulatory information in a developmental enhancer
News
Ross Munce passes Qual exam, part 1
He survived Struhl, Hobert, and Lomvardas.
Enhancer Fracking
Check out our newest collaborative paper with the Stern and Crocker labs, where a CRM was randomly mutagenized to death and the results analyzed in vivo using a high-throughput robotics platform.
Fuqua, T., Jordan, J., van Breugel, M.E. et al. Dense and pleiotropic regulatory information in a developmental enhancer. Nature (2020). https://doi.org/10.1038/s41586-020-2816-5
New paper: Selective loss TF-DNA complex binding as a consequence of compromising DNA shape recognition
In this paper, Judith Kribelbauer, who was a joint student with Harmen Bussemaker, significantly extended our understanding of how homeodomain protein complexes (Exd-Hox) bind to the correct binding sites in vivo. Judith generated an amazing amount of data for this paper: high-throughput SELEX-seq assays on wild type and mutant homeodomain proteins, ChIP-seq analyses of tagged homeodomain proteins from wing imaginal discs, and Hi-C data from wing discs to identify enhancer-promoter interactions.
Photos
Neuropils of the Drosophila VNC
Dendrites and cell bodies of a pair of tarsal depressor motor neurons
Image from Manntastic event, June 14, 2019