Image Carousel with 8 slides
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Slide 1: Series of embryos with Hox-Exd binding sites successively mutated in a reporter gene
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Slide 2: ""
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Slide 3: ""
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Slide 6: Word jumble for the Mann lab
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Slide 7: Stochastic flybow labeling of individual neuropil glia
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Slide 8: Human towers of Catalonia by David Oliete
Active Research Projects
The Control of Hox Specificity and Activity
We study how the Hox family of transcription factors bind to the correct DNA sequences and regulate the correct target genes in vivo.
Motor Neuron Development and Circuitry
We are studying how the neural circuitry that is required for coordinated walking in adult flies is constructed during development, and how it functions in the adult.
News
The end of EMSAs?
A new collaborative paper with the Bussemaker lab (Rastogi et al) was just published in PNAS. In this paper, we describe a powerful new computational tool, NRLB, that uses round 1 SELEX-seq data for any transcription factor to model the relative affinities of all binding sites. Thus the name: No Read Left Behind.
See also the Zuckerman Institute's news article here.
Cover of Neuron
On the cover: The photograph by David Oliete captures the more than two-century-old tradition of building human towers in Catalonia (Castells de Catalunya) and evokes the remarkable ability of biological systems to self-assemble into complex structures.
Building the CNS in flies
Differing Strategies Despite Shared Lineages of Motor Neurons and Glia to Achieve Robust Development of an Adult Neuropil in Drosophila
Jonathan Enriquez, Laura Quintana Rio, Richard Blazeski, Stephanie Bellemin, Pierre Godement, Carol Mason, Richard S. Mann
Photos
Cover of Neuron issue with our paper on how to build a CNS
Compartments in a wing imaginal disc
VNS, showing nuclei of glia
