Columbia | The Mann Lab

Slide 1: Tarsal depressor MN dendrites
Slide 2: Series of embryos with Hox-Exd binding sites successively mutated in a reporter gene
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Slide 4: bithorax fly; photo credit: Nicolas Gompel
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Slide 8: Stochastic flybow labeling of individual neuropil glia
Slide 9: Human towers of Catalonia by David Oliete
Slide 10: A fly leg imaginal disc
Slide 11: Four x-ray structures of AbdB-Exd bound to four different binding sites
Slide 12: Single serotonergic neurons in the fly VNC
Slide 13: bithorax fly side view; photo by Nicolas Gompel

dendrites color coded according to DV depth for a tarsal depressor MN

Series of embryos with Hox-Exd binding sites successively mutated in a reporter gene

bithorax fly; photo credit: Nicolas Gompel

Stochastic flybow labeling of individual neuropil glia

Photo by David Oliete used for Neuron cover

Four x-ray structures of AbdB-Exd bound to four different binding sites

Single serotonergic neurons in the fly VNC

bithorax fly side view; photo by Nicolas Gompel

Active Research Projects

The Control of Transcription Factor Specificity and Activity

We study how transcription factors bind to the correct DNA sequences and regulate the correct target genes in vivo, with a focus on the Hox family of homeodomain proteins.

Motor Neuron Development and Circuitry

We are studying how the neural circuitry that is required for coordinated walking in adult flies is constructed during development, and how it functions in the adult.

Full List of Research Projects