Image Carousel with 13 slides
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Slide 1: Tarsal depressor MN dendrites
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Slide 2: Series of embryos with Hox-Exd binding sites successively mutated in a reporter gene
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Slide 3: ""
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Slide 4: bithorax fly; photo credit: Nicolas Gompel
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Slide 8: Stochastic flybow labeling of individual neuropil glia
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Slide 9: Human towers of Catalonia by David Oliete
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Slide 10: A fly leg imaginal disc
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Slide 11: Four x-ray structures of AbdB-Exd bound to four different binding sites
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Slide 12: Single serotonergic neurons in the fly VNC
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Slide 13: bithorax fly side view; photo by Nicolas Gompel
Active Research Projects
The Control of Transcription Factor Specificity and Activity
We study how transcription factors bind to the correct DNA sequences and regulate the correct target genes in vivo, with a focus on the Hox family of homeodomain proteins.
Motor Neuron Development and Circuitry
We are studying how the neural circuitry that is required for coordinated walking in adult flies is constructed during development, and how it functions in the adult.
Recent Publication
FETCH enables fluorescent labeling of membrane proteins in vivo with spatiotemporal control in Drosophila
News
Farewell Kevin Rostam
Kevin Rostam, a Columbia Undergrad who started doing independent research in the lab in the fall of 2022, recently left the lab to meet new challenges. For the next year, Kevin is exploring new science in Erin Schuman's lab in Frankfurt.
Dr. Davys Lopez!
The Mann Lab sends a warm farewell to Genetics and Development student and long-time lab member Davys Lopez, who successfully defended his PhD last year, but stayed on in the lab to finish a few experiments. His work in the lab resulted in two papers, one published in PLOS Biology (doi: 10.1371/journal.pbio.3003030) and one in Genes & Development (doi: 10.1101/gad.352936.125).
Microscopic “Velcro” Sticks Brain Cells to Muscle
NEW YORK, NY — Like a puppet pulled by strings, your body is controlled by brain cells called motor neurons. But how do each of these neurons get connected to the correct muscles in the first place?
Photos
Kevin Rostam and his proud parents at graduation
Lab dinner
Dr. Davys Lopez
