Recent Publications

2025

FETCH enables fluorescent labeling of membrane proteins in vivo with spatiotemporal control in Drosophila

A critical affinity window for IgSF proteins DIP-α and Dpr10 is required for proper motor neuron arborization

Predicting the DNA binding specificity of transcription factor mutants using family-level biophysically interpretable machine learning

Decoding neuronal wiring by joint inference of cell identity and synaptic connectivity

Members of the DIP and Dpr adhesion protein families use cis inhibition to shape neural development in Drosophila

2024

Cover of the issue. Photographs by Nicholas Gompel.

HOX GENES: THE ORIGINAL BODY BUILDERS

A consortium of Hoxologists

2022

Transcription factor paralogs orchestrate alternative gene regulatory networks by context dependent cooperation with multiple cofactors

Siqian Feng
Chaitanya Rastogi
Ryan Loker
William Glassford
Tomas Rube
Harmen Bussemaker
Richard Mann

SpyChIP identifies cell type-specific transcription factor occupancy from complex tissues

Siqian Feng
Richard Mann

2021

An abx bx pbx/DfP2 four winged mutant. Photograph by Nicolas Gompel, University of Munich

Cell-type-specific Hox regulatory strategies orchestrate tissue identity

Ryan Loker
Jordyn Sanner
Richard S. Mann

Homothorax controls a binary Rhodopsin switch in Drosophila ocelli

Abhishek Kumar Mishra, Cornelia Fritsch, Roumen Voutev, Richard S Mann, Simon G Sprecher

Scarless engineering of the Drosophila genome near any site-specific integration site.

Siqian Feng
Shan Lu
Wesley B Grueber
Richard S Mann

2020

Types of changes to CRM activities after random mutagenesis

Dense and pleiotropic regulatory information in a developmental enhancer

Timothy Fuqua, Jeff Jordan, Maria Elize van Breugel, Aliaksandr Halavatyi, Christian Tischer, Peter Polidoro, Namiko Abe, Albert Tsai, Richard S. Mann, David L. Stern & Justin Crocker

A size principle for recruitment of Drosophila leg motor neurons

Azevedo AW
Dickinson ES
Gurung P
Venkatasubramanian L
Mann RS
Tuthill JC

Control of tissue morphogenesis by the HOX gene Ultrabithorax

Diaz-de-la-Loza MD
Loker R
Mann RS
Thompson BJ

2019

haltere imaginal disc with clones

A role for low affinity binding sites in fine tuning the levels of transcription

Rebecca K. Delker, Vikram Ranade, Ryan Loker, Roumen Voutev, Richard S. Mann

Low-Affinity Binding Sites and the Transcription Factor Specificity Paradox in Eukaryotes

Judith Kribelbauer
Chaitanya Rastogi
Harmen Bussemaker
Richard S. Mann

2018

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