Low affinity binding site review
In this review article published in the Annual Review of Cell and Developmental Biology, we argue that low affinity binding sites, which provide critical specificity for members of transcription factor families, co-evolved with transcription factor hubs, which increase the local concentration of transcription factors, thus allowing low affinity sites to be occupied.
July 23, 2019
Low affinity binding site review
In this review article published in the Annual Review of Cell and Developmental Biology, we argue that low affinity binding sites, which provide critical specificity for members of transcription factor families, co-evolved with transcription factor hubs, which increase the local concentration of transcription factors, thus allowing low affinity sites to be occupied.
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