Richard S. Mann


I studied retroviruses as a Ph.D. student at M.I.T. and Hox genes in Drosophila as a postdoc at Stanford. Since beginning my lab in 1990, we work on three big problems, all using the fruit fly as our experimental system: 1) how transcription factors find the correct targets and regulate the correct genes in vivo, with a special focus on the Hox family of transcription factors; 2) how appendages develop; and 3) how flies walk in a coordinated manner. This last topic includes both a developmental component (how leg motor neurons develop and establish the correct neural connections) and a behavioral component (what is the neural circuitry that governs coordinated leg movements). A consistent goal for our work is to solve problems at a mechanistic level, using a combination of genetics, biochemistry, and, in collaborative work, structural biology and computational biology. I enjoy mentoring students of all ages and backgrounds and strongly encourage members of the lab to explore their own ideas.


Featured Publication
Featured Publication
Where did insect wings come from?

Origins and Specification of the Drosophila Wing

David Requena, Jose Andres Álvarez, Hugo Gabilondo, Ryan Loker, Richard S. Mann, Carlos Estella